On a stormy night in the Low Country of South Carolina, Calico cat gives birth to five kittens under a small blue cottage. When the kittens are unexpectedly orphaned, the family living in the house above them brings them in and helps them to find good homes. Before the kittens are separated, they vow to reunite one day using the "inner voices" their loving mother told them to follow. Will they succeed? What roles will the animals of the Low Country play in their adventures? What dangers lie ahead for the kittens? Enter the world of Gus, Callie, Grace, Jim Bob, and Sugar to find out.