When the Lazy B Ranch is sold as a victim of the computer age, it seems that J.L. Crockett's way of life as a cowboy in the United States is finished. So he decides to pack up and move to Argentina, where ranches are still run by human beings. As J.L. begins a cross-country journey to Miami so he can board the ship to South America, he meets Karina, another soul chasing after an elusive dream. The two join together in a wild and crazy trip where they encounter evangelists, con artists, thieves, ghosts and drug lords as they bond together over hardship along the way. Will J.L., with Karina, make it to his next destination or will he really be The Last Cowboy?