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朱真一醫師有感於臺灣早期醫學史著作的不足，本著實事求是的精神，遍查資料、走訪相關人士，撰寫成本書，透過馬雅各（Dr. James L. Maxwell）、戴仁壽（Dr. George Gushue-Taylor）、安彼得（Dr. Peter Anderson）等醫療先驅的行誼及事跡，帶領讀者探尋臺灣現代醫學最初的篇章，並釐正坊間臺灣醫學資料的錯誤，並擺脫「台北觀點」，從台灣最早開發的台南，來述說台灣醫學史的發展。
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