Effective management of health facilities and agencies is particularly critical in settings where resources are limited in order to ensure that outcomes are maximized given the modest inputs available. With modest infrastructure, fewer healthcare professionals, and limited supplies of commodities, creative means of managing such scarce resources are needed to meet the health care needs of often large and impoverished populations. The papers in this supplement describe a set of quality improvement and strategic problem solving projects that demonstrate the positive and significant impact of good management on a range of outcomes including hand hygiene, hospital acquired infections, wound care practice, and medical documentation to facilitate effective communication among medical teams.