This e-book addresses the challenges of leading and managing knowledge intensive organisations, departments and administrations through formal knowledge strategies. It seeks to enrich knowledge management studies by broadening the focus from only the knowledge itself and the facilities for processing it, to an exploration of the differences arising from organisational, personal and leadership factors. It has been framed in the context of the strategic importance of knowledge, of people and of leadership in KIOs, both traditional and innovative, both locally and internationally, and to lay the groundwork for the development of theory, as well as offering well founded practical approaches. In line with the focus of the Journal of Knowledge Management on implementing formal knowledge strategies and approaches, the approach of this e-book is to emphasise the strategic approach to leading knowledge management in knowledge intensive organisations, rather than simply examining organisations which are acknowledged as knowledge-based.