In many ways information technology and systems are synonymous with the concept of innovation. This is especially true in healthcare, where providers of care continue to explore innovations regarding the electronic health record (EHR), decision support systems, computerized physician order entry systems and other innovative products to support them. Implementations of these innovations influence organizations, people's work activities and processes, and the tools they use. The authors in this e-book call for an extension of the innovations we've already adopted, raising the bar for innovative development and opening up new ways of using information systems in healthcare.