Hellboy, a bloodred, cloven-hoofed demon raised by the United States government, is a top field agent for the Bureau for Paranormal Research and Defense. He questions the unknown — then beats it into submission.

Religious artifacts from every faith are disappearing without a trace. The identity of the perpetrator is a complete mystery until Hellboy and Liz Sherman — acting on an unlikely tip from a ghost — foil a museum heist attempted by crude, robotic constructs inhabited by human spirits.

One of these freed human spirits offers to help Hellboy track down those who imprisoned him: a fanatical order of psychics obsessed with creating a new messiah, one that will bring about a new stage of evolution for mankind — whether mankind is willing or not. Now only Hellboy and his colleagues stand between a vulnerable humanity and an evil, vengeful god....