Jamilet is a beautiful young woman marred by a shockingly gruesome birthmark. It spills over her back and down her legs, twisting and writhing like a hideous cape of blood, causing her to be shunned by the villagers of her rural Mexican town. In search of medical salvation, this angel with the devil's mark is finally driven to escape north and cross the border illegally to Los Angeles.

After acquiring false documents, Jamilet finds work at a mental hospital, where she is assigned to look after Señor Peregrino, an elderly man from Spain who is as disagreeable as he is mysterious. Jamilet is given strict orders to keep her distance, but when he cleverly snags possession of her papers, he bargains to return them upon the condition that she listen to his story. Jamilet begrudgingly agrees, and Señor Peregrino takes her back to the days of his youth, when he embarked upon a mystical and romantic journey along the legendary Road to Santiago in Spain.

Jamilet and Señor Peregrino forge a spiritual bond that is more healing to them both than modern medicine could ever be. In an inspiring story of redemption, faith and the enduring power of love, Samartin offers an enlightening perspective on the true meaning of beauty.