With its depictions of the downtrodden prostitutes, bootleggers, and hustlers of Perdido Street in the old French Quarter of 1930s New Orleans, A Walk on the Wild Side found a place in the imaginations of all the generations that have followed. "I found my way to the streets on the other side of the Southern Pacific station, where the big jukes were singing something called 'Walking the Wild Side of Life,'" wrote Algren. "I've stayed pretty much on that side of the curb ever since."

Perhaps the author's own words describe this classic work best: "The book asks why lost people sometimes develop into greater human beings than those who have never been lost in their whole lives. Why men who have suffered at the hands of other men are the natural believers in humanity, while those whose part has been simply to acquire, to take all and give nothing, are the most contemptuous of mankind."