Grappling with her daughter's fatal accident, Joanna finds solace in the conviction that her daughter lives on in the body of another child. Nancy's decision to lose a kidney in order to save her husband's life jeopardizes her last chance for motherhood. All that Barbara possesses and identifies with, including companionship with a ghost, vanishes overnight. Angie takes a drastic measure to lose weight in order to regain her confidence and self esteem. Rosemary, a renowned "agony aunt," falls apart when her husband leaves her, only to find comfort in the strangest of strangers. Love and the supernatural drive these stories about the intertwining lives of five female cousins, who learn that loss—from misplacing keys to confronting death—is a constant force.