Blacksad is in Las Vegas, with both his finances and morale at rock bottom, working for a wealthy gambling man. However, an unexpected encounter shakes up his new life: his friend Otto Lieber, a high-profile scientist, is in town for a nuclear conference. The two men manage to find the time to get together and chew the cud. Otto seems to be leading an exciting life, despite the little eccentricities of his "benefactor," Gotfield. Gotfield is married to the gorgeous Alma... on whose account Blacksad's life will take a surprising turn...