Harry and Anastasia are back, this time married and attempting to fit into society. When another transgenic emerges—a mole-man named Leonardo—he tells them an old friend, Istvan, a pig-man, long thought dead, is still alive.

Doing the right thing, Harry and Anastasia go to investigate and find out other transgenics are alive, well, and led by yet another madman, bent on destruction. The trail begins in Italy, and continues on to France, Spain, and finally back to the United States.

As if that wasn't enough, Anastasia is pregnant and Harry has to worry about her, the baby, and the plans of the madman who hates all transgenics and wants to see them eliminated. Anastasia's life is threatened as is the life of her baby, and with the outcome far from certain, the quest continues.