Brooke and Mary Rose are best friends. Brooke is the mother of a six-month-old. Mary Rose is pregnant. Brooke is married to Lyle, though, at times, she wonders why. Mary Rose would be married if Ward, the father of her child, weren't already. Ward and Brooke are cousins... A comedy of manners and biology, Karbo gives a laugh-out-loud look at the wonders of pregnancy and motherhood. It is a world where the women are fierce and strong and the men duck and cover; a world that is turned upside down when the expecting mother turns out a most unexpected child. Motherhood Made a Man Out of Me celebrates the courage and strength of women and the bonds that join them “in the motherhood."