It begins when hardheaded mountain matriarch Granny Mustard decides she wants to live forever, but is killed before she can achieve her goal. Her slow-witted but equally hardheaded granddaughter Jenkie decides to pick up the ball and run with it. She takes Granny's unperfected immortality moonshine recipe, a socially-inept friend named Bink, and her wild dreams of fame and fortune to an abandoned trailer up in Desper Hollow.