The research area of simulation based decision support has grown substantially in recent years. Several types of systems have been presented and analyzed in the literature, primarily from a theoretical and conceptual standpoint. However, some have had simulation applied and/or field experiments conducted. The maturity level of the approaches presented in the literature is low. Hence, there is a lack of research concerning industrial case studies in general and real-life implementations and applications (deployed systems) in particular.This e-book aims to contribute to the understanding of simulation based decision support systems in the supply chain context by illustrating its connection and value in real-life. Our main interest is in practical implementations and applications (deployed systems), even if theoretical and conceptual research works in the area are also considered.