Theology needs to engage what recent developments in the study of evolution mean for how we understand moral behavior. How does the theological concept of holiness connect to contemporary understandings of evolution? If genetic explanations of altruism fall short, what role should we give to environmental explanations and free will? Likewise, how do genetic explanations relate to theological accounts of human goodness and holiness? In this groundbreaking work, Matthew Hill uses the lens of Wesleyan ethics to offer a fresh assessment of the intersection of evolution and theology. He shows that what is at stake in this conversation is not only the future of the church but also the fine-tuning of human evolution.