A prodigious young chemist, Dr. Steven J. Fisher, has devoted his research to studying the complexities of the female orgasm from behind his computers. But though he thinks he has sex down to an exact science, the shy doctor is a beginner in the ways of love. When a beautiful and orgasmically-challenged Ph.D. student named Annie begins participating in his study, everything Dr. Fisher thinks he knows about women is turned on its head.

Cleverly presented through excerpts from Steven's clinical study and Annie's blog entries, this charming love story gets to the heart of what makes us all tick, showing that romance, though far more than a chemical equation, is, in fact, all about chemistry.