In Greek Mythology, Pandora's Box held all the evils of mankind, creating a barrier between humanity and those evils. In today's modern world, Pandora's Box is a facility that imprisons a group of sub-humans known only as Residents. Each Resident is engineered with mysterious and horrifying power, thus making them a danger to mankind and Pandora's Box prisoners.

The Residents, unstable and at times perverse, are seeking an opportunity to free themselves from the restraints of Pandora's Box, but their freedom could potentially unleash unspeakable horrors onto the world.