One hundred years ago a deadly super-virus infected all of humanity—and killed all the men—making it impossible for boys to be born alive. Women, alone, have been ruling the world ever since.

When a cure for the super-virus is eventually discovered—men are able to be born again—and the women begin reintroducing boys back into society. However, there are some who are not happy about the return of men to civilization. A secret cult of man-killers, called the Sicarii, plot to make sure that men stay extinct forever.

Nancy Rose is a young US federal agent under the powerful Department of Safety—an institution that insists everyone conform to their safety rules or else. She and her fellow agents are specially charged with the protection of boys from the murderous Sicarii.

When Nancy receives a tip that leads to a party for man-killers, she is put on a path to confront one of the queens of the Sicarii—the mysterious Queen of Spades. Nancy will need to shoot from the hip, aim straight, and watch her back —plus keep her own secrets from being uncovered— in order to stop the man-killers before it is too late.