When Wyoming rancher Sam Gallagher advertises in the New York Times for a housekeeper, a young woman with a venturesome spirit, Meg Wolverton, accepts the position eagerly. Being short on travel money, Meg hires on with the Children's Aid Society to help transport thirty homeless waifs from the slums of New York to loving homes all across America. The orphan train stops at every whistle-stop town along the way, hopefully matching up these rambunctious orphans with suitable families. But alas, a few manage to slip through the cracks. To be specific, three children still need homes-as Meg discovers to her dismay, upon arriving in Cheyenne. To make matters worse, Meg's new employer is late meeting the train.
Will he show up? Will she lose her job and wind up destitute, with three un-adoptable orphans to support? Or does God have a better plan?