Cheryl Beth Wilson, a nurse at Cincinnati Memorial Hospital, finds a doctor brutally murdered in a secluded office. Wilson had been having an affair with the doctor's husband, a surgeon, and now she is a "person of interest," if not an outright suspect. But someone other than the police is also watching Cheryl Beth.

The murder comes as former homicide detective Will Borders is just out of surgery. But as his stretcher is wheeled past the crime scene, he knows this is no random act of violence—in fact, it has all the marks of a serial-killer case he supposedly solved years before. Unable even to walk, Borders starts to investigate, teaming up with Cheryl Beth, who is desperate to clear her name. But as the killer grows closer, the two are running out of time to unlock the secrets of the murder at the brooding, old hospital.