Best friends, Casey and Rachel couldn't lead more different lives. While workaholic Casey rubs elbows with celebrities daily as the host of Gossip TV and comes home nightly to an empty apartment, stay-at-home mom Rachel juggles a baby, two teenagers, and a husband who barely seems the man she fell in love with two decades before. After an argument at their twentieth high school reunion, Casey and Rachel throw back shots to get the night back on track. Instead, they get a life-changing hangover. Waking up in each other's bodies the next morning, they must figure out how to navigate their altered realities. Rachel is forced to face the broadcasting dreams she gave up when she got pregnant in college, and Casey finally steps out of the spotlight to face the real reason why she's alone.