As a new president takes the White House, Just Cause returns to New York City for the first time in eight years, under the command of its newest leader: Mustang Sally.

But not everyone is excited about the expansion of Just Cause. Senator Christine Goodwin, slighted by the team's leadership years before, has made it her mission to put all parahumans on a very short leash, while at the same time creating her own super-powered militia.

With the media and America at large turning against Just Cause, Sally and her teammates must risk their lives and freedom to halt the Senator's plans, which threaten the futures of parahuman people worldwide.