Emma Caldridge, a chemist for a cosmetics company, is en route from Miami to Bogotá when her plane is hijacked and spins out of control into the mountains near the Venezuelan border. Thrown unhurt from the wreckage, she can do nothing but watch as guerrillas take the other passengers hostage.
An endurance marathon runner, Emma silently trails the guerrillas and their captives, using her athletic prowess and scientific knowledge to stay alive. Those skills become essential when she discovers an injured passenger, secret government agent Cameron Sumner, separated from the group.
Meanwhile, as news of the hijacking breaks in Washington, the Department of Defense turns to Edward Banner, former military officer and current CEO of a security consulting firm, for help. But finding Emma and Sumner is only the beginning, as Banner starts to realize that Emma was on a personal mission when the plane went down.