Joseph Vogorev hates spiders and loves money. As the president and CEO of chemical giant Pest No More, he develops a neurotoxin pesticide specially formulated to target only arachnid species. When outspoken environmentalist Gale Pacalis realizes the potential for planet-wide devastation, he wants more than anything to bring Vogorev down. With a host of quirky friends, he collects data to prove Arach-No-More's lethality. Teenaged Amelia joins his group because she's personally invested; her pink kneed tarantula, Pinky, died. It's a race to save the world, but as Gale and his friends go head-to-head with Vogorev, the many obstacles they face makes it seem impossible to win. Mainly because Vogorev has unlimited money and a limited conscience.