Ion-Selective Electrode Reviews, Volume 6 covers new fields of application for coated-wire ion-selective electrodes (ISEs). The book discusses the practical suggestions for testing automatic equipment based on ISE; the amperometric and potentiometric determinations with immobilized enzymes and microorganisms; and the drug-type substances analysis with membrane electrodes. The text also describes coated-wire ISEs and the in vivo application of ion-sensitive field effect transistors, including a summary of laboratory research and probable future clinical detectors.