A Picasso painting, worth a hundred million dollars, disappears en route from Chicago to New Hampshire. Literally—en route. The painting goes missing while the truck is moving. The painting is there, then it's not. It's gone, but it can't be. Kendra Jean Valentine, underwriting agent for the policy, is on the hook. She scrapes together enough to hire two women to work the case. Westen Hughes owns a failing pet shop. With creditors phoning daily, she jumps at the chance to earn a bundle of easy money, even though the offer comes from her old nemesis KJ Valentine, who stole everything in high school: head cheerleader, homecoming queen and the star quarterback. KJ pairs her with Westen's total opposite: Phoebe Smith, a snake-loving, underwear-hating, tuba player with more baggage than Logan Airport. Ten percent of a hundred million is...well, it's a lot so Smith and Westen join forces on a rollercoaster ride to find one of the world's most valuable paintings.