Flo and Mo are not ordinary babies. Although only fourteen months old, they can use a computer, trick any mindless adult they want, and help their goofy detective father solve some of the most baffling of crimes. The only thing they struggle with is controlling the natural actions of their tiny, baby bodies. Therefore, they need to be changed and burped regularly.

Then a mysterious girl comes to their father, claiming that her grandmother has disappeared. Soon the babies find themselves launched on a mystery that challenges even their incredible minds. In the midst of Indian attacks and kidnappings, will the babies be able to save their bumbling parents?