Two mixed-blood young people, each with a different vision of what life should be. Two lovers, kept apart by their beliefs. Two nations, the Blackfoot and the United States, at sword's point.

St. Louis-educated Marie Therese de Paris returns to her people in Montana determined to preserve their ways. She becomes a seer, a medicine woman, of the Blackfeet, and lives the dedicated life of a prophet on the Two Medicine River. Peter Kipp, son of an American Fur Company trader, wants to enter his father's world and live as white men do. The two young people love each other, but cannot find the common ground they need to come together.

And then the United States Army arrives, determined to subdue a people who are not at war. And the world of the young people is torn apart forever.