Jake Cutter sets out to avenge the death of Uncle Bob Hammond by the Arivaipa Apache chief, Chachu and his band of Comancheros, who also carried away four women from a wagon train to sell down in Mexico. Charlie Pickett, a deadly gunfighter who swore to kill Cutter, but is forced to wait until they can rescue his twin sister, one of the captives. Sickened by the thought that perhaps his brother, Adolpho, is part of the band, Jake doggedly tracks the savages down to the Sierra Madres for a showdown with a personal difference.