After a tumultuous, fatherless childhood, Johnny Castillo tends to date women his mama doesn't approve of, and for good reason. Tired of relationships that end badly, he turns to Madame Eve's 1Night Stand dating service for help. He's seen what her incredible matchmaking skills have done for his cousins and friends, and he's open to her helping him find a woman he can have a future with. If that's even possible.

Carmen Sanchez has put up a strong fight against the cancer attacking her body and she's ready to start living life once more. With the results of her latest medical tests unopened and tucked in her purse, she enlists Madame Eve in her search for the right guy to share a weekend of lusty pursuits, before unsealing the envelope and discovering her fate.

But Johnny and Carmen's date includes a battle where the stakes are high—life or death. Love may conquer all, but Death has something else in mind. Is their newfound love strong enough to win the battle?