The e-book serves as a valuable platform for new theory and research that integrates multidisciplinary perspectives in describing, explaining, predicting, and influencing culture, tourism, and hospitality in the U.S. Southern States. This region of the United States is distinguishable from other regions by its cultural values and practices. Tourism in the U.S. South is multi-faceted and includes destination-based, ritual-based, heritage-based, and experiential-based attractions. The articles touch on these various aspects of Southern-based tourism and reveal its unique attributes as it relates to culture and Southern hospitality.