A weekend getaway to New Orleans takes a dangerous turn when four women attract the hungry attention of scavengers, creatures once lured to the Big Easy to feed on the dead - but who have now moved onto the living.
The women must run for their lives, seeking refuge from the Garden District to the Ninth Ward as the scavengers hunt them down. A cocky Irish movie star with a mysterious curse offers to help - but his assistance quickly turns into trouble.
Sneaky vampires join the chase, eager to exploit the women in an attempt to bring down the scavengers, their sworn enemy and chief competition for pretty human flesh.
Relying on their wits, humor, and a few hidden talents, the four friends battle to stay alive during one wild night in New Orleans.