Gene Regulation documents the proceedings of the CETUS-UCLA Symposium ""Gene Regulation,"" held in Keystone, Colorado in March/April 1982. The symposium related gene structure and regulatory sequences to overall genomic organization and genetic evolution. It was the first meeting to focus on regulation of eukaryotic gene expression since the maturation in recombinant DNA technology. The book is organized into four parts. Part I presents studies on the structure of eukaryotic genes, including the organization and molecular basis for differential expression of the mouse λ light chain genes; globin gene transcription and RNA processing; and the cloning of the human chromosomal α1-antitrypsin gene and its structural comparison with the chicken gene coding for ovalbumin. Part II on chromatin structure includes papers on nuclease sensitivity of the ovalbumin gene and its flanking DNA sequences; and the relationship of chromatin structure to DNA sequence. Part III on gene expression includes papers on the role of poly(A) in eukaryotic mRNA metabolism and the in vitro transcription of Drosophila tRNA genes. Part IV on cellular biology includes studies such as the importance of calmodulin to the eukaryotic cells.