When Swedish immigrant Alexandra Bergson inherits her family's Nebraska farm upon her father's death, she struggles to save her livelihood. The stalwart Alexandra refuses to give up, even as many other families abandon their dreams of a life on the prairies. While working to make the farm profitable, Alexandra must also contend with her feelings for Carl Linstrum, and deal with her brother Emil, who is involved in a risky affair with a married woman.

The first novel in Willa Cather's seminal Great Plains trilogy, O Pioneers! was published in 1913. It has since been adapted into an opera and the 1992 Hallmark Hall of Fame television movie starring Jessica Lange, David Strathairn, and Anne Heche.

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