In the Hispanic/Latino culture, a folk healer is called a "curandero." Noe's grandfather, Santiago, was a wise and powerful healer who, in the end, could not cure or save his own daughter, Noe's mother. As child Noe made the decision he would become a "real doctor" even though his grandfather kept telling his grandson he inherited "el don," the gift of healing.

Years later in medical school, Noe is unaware that both he and his grandfather have been hunted by a coven of Mexican witches because of who Noe is and what he can produce. Noe's weakened and aged grandfather is slowly dying in a nursing home as the world around him begins to change and Noe's girlfriend is kidnapped.

Does Noe really has special powers and if he does can he control and use them as the witches close in? A story of the supernatural but also of faith, The Evil Eye is a modern tale of mysterious threats and powerful belief.