The story of Sara Bear takes you on an exciting and intriguing journey full of action, mystery, murder, and adventure. It is the story of a young woman raised by Indians in the American wilderness of the 1840's. She escapes her violent husband and tries making her way east. Shortly after her journey begins, she comes across the remains of a hostile attack against a family's wagon. As the father lay dying, he asks Sara to help his four children make it to safety. Sara reluctantly agrees and the children soon learn that without her help, they would be lost for sure.

After another attack on their party, Sara begins to think there is something suspicious about the children's situation. Finally the travellers arrive at an outpost, but Sara learns that they are unable to help. They do, however, offer to escort her to the railhead where she can get passage to Philadelphia for her and her party.

Once there, Sara is hoping to reunite the children with the relatives of the slain parents, thus fulfilling her promise. Sara soon finds that her life becomes intertwined with her newly adopted family as she uncovers a string of events involving the children's parents, their relatives in Philadelphia, and a pair of foreign assassins.

Sara and the children return to the western wilderness with additional family members from Philadelphia where they establish a ranch and begin work on making a new life for themselves. However, their trouble does not end as hired Comanchero's are still on the lookout for the children and other family members.