Sassy Abigail Andrews is a phlebotomist who has terminal leukemia. The good news is that her Dr. Jakob Farkas might be able to heal her, since he claims to be a vampire. But there's one small hitch, tired of his lonely existence, Farkas has not fed in over 100 years and needs to be brought back to health before he can help Abigail, with whom he has fallen in love.

Abigail doesn't believe the crazy doctor's story, but she doesn't have much else going on at the moment besides dying. So she leaves her boring life behind in order to join Jakob Farkas on his travels around the world in search of a mystical cure.

As they await the arrival of the Spring Equinox in the legendary caves in Lascaux France, Abigail wonders if she can overcome the greatest obstacle to her cure: her mortality.