Richard McCain is a retired Special Forces operative whose underground activities during the Tribulation Era of American history places him on the FBI's Most Wanted list as the mysterious Destroyer. He is called upon by his ex-wife to rescue her sister from the tragedy of a "dirty bomb" terrorist strike in Mexico City. In doing so, he is forced to rely upon the Angel Train network of Christian activists spread across the country. The network, a major target of Homeland Security, absorbs the full force of the agency's technological arsenal as no effort is spared to seek and destroy McCain. In a series of supernatural events, McCain realizes that there are even greater forces at play threatening his life and that of the beautiful Isabel. It seems that only a miracle can save him, and at last he finds the answer to the ultimate question: is God truly in control?