Cathy Nelson is young, successful career woman and mother who is mortified when her husband, Adam, trades in a prestigious research career to become a high school science teacher. But as unhappy as Cathy is, she is reluctant to taint her image with a messy divorce. However when Cathy embarks on a steamy affair with a co-worker, she becomes desperate to end her marriage.

The breaking point comes when Cathy learns that her company is about to go public. When Cathy tells Adam about her company's plans, her husband threatens to expose the life-threatening side effects with the drug that had surfaced in his research. If he reveals what he knows, Adam could derail the IPO and destroy her career. Cathy is left with no choice in her mind but to kill her husband.

Toni Ambrose is a young, but relentless detective, assigned to the murder case. Her instincts tell her that Cathy is guilty and she defies her superiors to doggedly build a case against this black widow disguised as a grieving wife.