This report contributes to the design and implementation of policies that promote healthy living in Latin America and the Caribbean (LAC), thus effectively preventing premature mortality from non-communicable diseases (NCDs) in the region. It examines the health and economic impact of NCDs in the region and the governance challenges in the design and implementation of multisectoral policies to prevent these conditions, including polices to improve diet, increase physical activity, and reduce tobacco use and alcohol abuse. The study focuses on how policy decisions involving multisectoral interventions to prevent health risk factors are taken, which stakeholders directly or indirectly participate in those decisions, which incentives they experience, and what strategies they use in these processes. This document is divided into six chapters: 1) non-communicable diseases in Latin America and the Caribbean, 2) risk factors for NCDs in Latin America and the Caribbean, 3) economic impact of NCDs in Latin America and the Caribbean, 4) governance of multisectoral interventions to promote healthy living: international examples, 5) multisectoral interventions to promote healthy living in Latin America and the Caribbean, and 6) lessons learned and agenda for the future.