The quarrels with her father, the prejudices against women, her secret alliance with the legendary Cabeza de Vaca, the political ambitions of these times, these are only some of the problems she had to pass to realize this expedition. But this is just the beginning of her eventful expedition where a rough German joins the group and they try to fulfil their destinies trying to conquer this new world.

María de Sanabria es la historia de una joven noble sevillana que lideró una expedición al Río de la Plata protagonizada por mujeres en el siglo XVI, con la ayuda del legendario Alvar Núñez Cabeza de Vaca.