After seven long years in the Delta Quadrant, the crew of the Starship Voyager now confront the strangest world of all: home. For Admiral Kathryn Janeway and her officers, Voyager's miraculous return to planet Earth brings new honours and new responsibilities. For some there are reunions with long-lost loved ones, while for others such as the Doctor and Seven of Nine, there is the challenge of forging new lives in a Federation that seems to hold little place for them.
But even as Janeway and the others go their separate ways, pursuing new horizons and opportunities, a strange cybernetic plague strikes Earth, transforming men, women and children into a new generation of Borg. Soon the entire planet faces assimilation, and Voyager — newly returned from the heartland of the Borg — may be to blame.