Gaia and The Temple are habitats, part of a fleet taking colonists fleeing their dying star system to begin again on a new world. Gaia's passengers are isolated from the main fleet. Their atheist views conflict with the strict religious beliefs controlling the rest of the society.

Scientists in Gaia, no longer restricted by regulations, investigate genetic manipulation and produce people with enhanced intelligence. Their discovery is restricted to their own society, parents who desire intellectually enhanced children need to purchase unreliable black market enhancements.

The enhancements of two young women, Ione and Thisbe mutate and produce the most intelligent and talented two people in Gaia. They, together with the android, Rhea, are sent to the strictly superstitious people of The Temple, to seek a cure for a sickness sweeping Gaia. The trio find the previously peaceful society has descended into anarchy. They become caught up in a battle between superstitious zealots and drug crazed madmen who are supported by ancient robots designed for one purpose, to kill people.

The challenges the girls face increase their abilities. Ione becomes thought of as a miracle worker and Thisbe finds new talents within her that go far beyond her already recognised abilities.