TheAntichrist is the most powerful criticism ever offered against modern values and beliefs. In earlier books Nietzsche had announced, "God is dead," and in The Antichrist he seethes with contempt for Christianity's imposition, upon humanity, of its perverse and unnatural vision.

Nietzsche contends that values offered by Christianity are created by people who are not qualified to create such values and ideals. These meanings and goals are unnatural distortions of reality provided by people who are themselves divorced from reality, and who seek to instill in others the same dissatisfaction with this world which infects them.