Detroit homicide Detective Bonnie Benham has been transferred from narcotics for using more than arresting and is working the case of a killer of adolescent girls. CSI collects DNA evidence from the scene of the latest victim, which had not been detected on the other victims. But no suspect turns up in the FBI database. Due to the notoriety of the crimes a task force is put together with Bonnie as the lead detective, and she implores the D.A. to use an as yet unapproved type of a DNA Search in an effort to identify the killer. Homicide Detective Neil Jensen, with his own history of drug and alcohol problems, understands Bonnie's frailty and the two detectives become inseparable as they track this killer of children.