Set in fictitious Yoknapatawpha County, Sanctuary is the moving story of the vagaries of justice in the aftermath of a horrible crime. The daughter of a local judge, Ole Miss university student Temple Drake is kidnapped and assaulted by Popeye, a sinister criminal and head of a gang of moonshiners. On the run from Popeye, Temple finds sanctuary at a brothel, where she is discovered by lawyer Henry Benbow, while the hapless Goodwin is falsely accused of Popeye's crime.

Published in 1931, Sanctuary established William Faulkner's literary reputation, and, because of its subject matter, continues to be considered one of his more controversial novels. Faulkner revisited the character of Temple Drake in Requiem for a Nun, published in 1950. Sanctuary has been adapted for film twice, first in 1933 as The Story of Temple Drake, and then again in 1961.

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