There's a new student in Calvin's class, a boy named Owen. Mrs. Gilson, their teacher, asks Cal to show Owen around. Cal is curious about Owen, because he overheard Owen's mother telling Mrs. Gilson that Owen has burgers and drum. Where could Owen be keeping his burgers and drum? Are they in his backpack?

Owen tapes the classroom rules to his desk, speaks too loudly and steals the ball when the students try to play soccer at recess. Cal can't figure out if Owen wants to be friends or not and he still hasn't found Owen's burgers and drum. Cal tells his mom about Owen. She explains that Owen doesn't have burgers and drum, he has something called Asperger's Syndrome, which gives him a different learning style but he still could become a good friend.

One day Owen finds Cal and his friend Andrew goofing off in the hallway during class. Suddenly the fire alarm goes off. Owen finds a way to save the school and his future friends.

Owen Has Burgers and Drum is a fun story addressing the difficulties and rewards of befriending a child with Asperger's Syndrome. At the end of the book, the authors provide tips and suggestions to help parents and educators talk with children about Asperger's Syndrome and to help children better understand kids with an autism spectrum disorder.