Medea lives in the ancient kingdom of Colchis, under the oppressive rule of her father, Aeëtes, a descendant of the sun god Helios. Her life as a priestess of Hecate is one of quiet solitude with her loyal dog, spent tending to the temple and honing her sorcery for medicinal purposes. When she crosses paths with Jason and the Argonauts, she enters the classic myth often retold to glorify the hero's triumphs.

Jason is unwittingly a pawn of the gods, sent by Hera to claim the Golden Fleece. Hera's manipulation drives Medea to fall in love with him. Jason exploits her sudden devotion to help him win the Fleece, while she believes she is choosing a life with Jason and escaping Colchis. Her gifts soon become a curse as she aids the Argonauts with increasingly dark magic, and begins to question her own mind.

Medea is a tale of love, betrayal and the pursuit of justice. It is the story of a woman wronged by the influence of men and gods, and of her struggle to reclaim her destiny.