This volume focuses on translational models of pediatric brain cancers that are critical to understanding tumor formation, tumor progression, and response to treatment. These models are particularly important for drug screens and preclinical testing of novel treatment approaches involving chemotherapy, radiation, and immunotherapy. The chapters in this book cover a variety of the latest technologies used to investigate the molecular backbone of pediatric brain tumors. These new diagnostic tools include tumor characterization from liquid biopsy; capturing the local heterogeneity of a single tumor through spatial genomics; and deciphering the unique epigenetic traits of pediatric brain tumors by profiling tumor methylome and post-translational histone modifications. Some chapters also describe the latest experimental tools designed to explore new therapeutic strategies and optimize current treatments. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and thorough, Translational Research Methods for Pediatric Brain Tumors is a valuable resource for clinicians and researchers who want to learn more about experimental pediatric neuro-oncology and help guide the field toward a brighter future.